There are clear requirements for standardization, quality assurance and control at each step in the radiomics process.
QIPCM, in collaboration with UHN’s Radiation Medicine Program, has validated tools and services for:
- Imaging data curation across different imaging databases
- Meta-data extraction and quality assurance review (image acquisition parameters such as Tube voltage, slice thickness and scanner model; and reconstruction parameters such as voxel size)
In order to facilitate the process of data curation, meta-data filtering and feature extraction, the MIRA platform, built by Dr. Tony Tadic, Dr. Nathan Becker and Tirth Patel at the Princess Margaret is used. MIRA is a web application and software framework for automating data science and integrating image processing pipelines (e.g. pyradiomics, deep learning modules) with clinical systems such as Raystation, Mosaiq and various DICOM PACS and databases.
Dr. Lillian Siu, Dr. Anna Spreafico, Dr. Scott Bratman and Dr. Benjamin Haibe-Kains at Princess Margaret Hospital have been working with QIPCM for both the INSPIRE (https://clinicaltrials.gov/ct2/show/NCT02644369) and ROMA (https://clinicaltrials.gov/ct2/show/NCT03759730) trials. INSPIRE is a single centre, nonrandomized, multi- cohort trial of pembrolizumab in subjects with advanced solid tumors. The goal of ROMA is to evaluate the role of microbiome as a biomarker in locally advanced oropharyngeal squamous cell carcinoma.